Josh Olson and Sean Campbell began independently homebrewing in the early 2010s and started brewing together in 2017. After a few years, they began discussing turning their hobby into a profession. Plans to open in a different location were put on hold during the COVID pandemic, but in the middle of 2021, they again began looking for a property. Later that year, they finalized the purchase of 231 Vestal Ave. in Endicott, New York, and began construction. They opened to the public in December 2022.

Olson and Campbell aim to make highly drinkable and balanced beers. They want their tap list to be something that anyone, from someone brand new to craft beer to a seasoned veteran, can find something that they will enjoy. They do this by having four flagship beers that are available year-round and four more offerings that rotate seasonally. They also carry a variety of New York state cider and wine.

Flagship beers include Casper the Friendly Cream Ale, an easy-drinking cream ale for the beginner and connoisseur alike; Cousin Kevin American Pale Ale, billed as everything you want in an American pale ale; Herbert Session IPA, a highly crushable beer pale in color, dry in finish and a great platform to showcase a dry hop of Citra, centennial and Amarillo; and Moon Juice New England IPA, which has a softer malt presence with El Dorado, mosaic and sabro hops.

The tasting room consists of 10 seats at a live-edge bar, 16 bar-style seats at pub tables, 20 seats at five restaurant-style tables as well as an area for standing room. For entertainment, they have three TVs that are usually playing a variety of sporting events, as well as a playlist that typically wanders from the 1970s through the early 2000s. They also offer nights for open-mic standup comedy, trivia and live music. Crooked Mouth Kitchen has a full food menu that specializes in gourmet sandwiches, including beef on Weck, Reuben and intriguing variations on grilled chicken.